cancer

Turmeric, Curcumin, and Cancer: What’s the Research?

by Columbia Surgery on March 26, 2014

Turmeric Blog3Deborah Gerszberg, RD, CNSC, CDN
Clinical Nutritionist
The Pancreas Center

Turmeric is a root, appearing similar to ginger, with a very mild bitter and spicy flavor, often found ground in the spices section of your grocery store.  As one of the main spices found in curry, you may recognize turmeric by its bright yellow/orange hue. Due to its mild flavor, many chefs are incorporating turmeric into their dishes solely for its bright color!

One of the components found in turmeric is called curcumin, which is an antioxidant in the polyphenol family that has anti-inflammatory, anti-viral, anti-bacterial, and anticancer properties.  Used for centuries in Chinese and Indian medicine, turmeric has been used to treat a wide range of ailments including various skin conditions, respiratory disorders, gastrointestinal distress, and infections (parasitic, viral, and bacterial alike).

In addition to its widespread ability to help treat many ailments, there are few side effects for the majority of people. The major drawback in using curcumin has been a low bioavailability, therefore the formulation and delivery of the substance must be carefully considered. The use of nanoparticle technology has allowed for increased bioavailability, resulting in up to 27 times greater absorption in human studies when taken orally. Traditionally, turmeric is used with black pepper in cooking. Piperine, a main component in black pepper, has been shown to increase curcumin bioavailability by 2000%.

Much attention has been paid to curcumin use for cancer prevention and treatment including leukemia, breast, colon, prostate, and pancreatic cancer.  Studies have shown curcumin increases tumor cell death (apoptosis) while stopping tumor cell growth (proliferation). Researchers injected human pancreatic cells into mice to study the effects of liposomal curcumin on tumor growth and discovered the mice given curcumin had a 42% decrease in tumor growth compared to untreated mice.

Researchers studied the effect and tolerance of a nanoparticle formulated type of curcumin (Theracurmin®) given orally to patients with advanced pancreatic or biliary cancer with gemcitabine based chemotherapy.  Patients reported improvements in fatigue, overall function, and appetite. Toxicities were comparable with those expected from standard. Two patients reported increased abdominal pain after receiving Theracurmin® however both patients had dilated colons. Since curcumin can be an intestinal irritant, the authors recommend caution in the use of curcumin in such circumstances. Listed as a potential conflict of interest, two of the study’s authors are involved with Theravalues Corporation, the company that manufactures Theracurmin®.

What does all this mean for you or your loved ones suffering with pancreatic cancer?

Curcumin has been shown to be effective in limiting tumor growth in controlled animal based studies. A small phase 1 human trial showed curcumin is generally well tolerated when given with chemotherapy and may improve certain aspects of the patient’s quality of life.

While it may be too soon to run to your local supplement store and stock up on curcumin in pill form, feel free to add turmeric (remember that yellow spice that curcumin is found in?) to your food. Turmeric compliments salads, casseroles, and omelets well. Don’t forget to sprinkle on some black pepper to make sure you absorb well, and feel free to enjoy this golden spice as part of your diet!

A word of caution

Mega doses of curcumin may worsen certain conditions such as gall bladder problems, reflux, or other gastrointestinal disorders. If you are taking blood thinners, or are having surgery within two weeks, you should avoid supplemental curcumin as it may cause extra bleeding. Always discuss taking a supplement with your health care provider to be sure it will not interfere with your medications or worsen any medical conditions you may have.

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pancreas, WhippleOn March 4, 2014, the first robotic Whipple procedure was performed by Dr. John Chabot, Executive Director of The Pancreas Center, and Dr. Yanghee Woo at NewYork-Presbyterian/Columbia University Medical Center.

This is exemplary of The Pancreas Center’s mission to continually advance the quality of pancreatic care.

What is a Whipple Procedure?

For those who may not know, the Whipple procedure is an operation in which surgeons remove the head of the pancreas, which constitutes almost forty percent of the pancreas, as well as the duodenum, the first section of the small intestine. This piece of the intestine is closely attached to the head of the pancreas, so they must be removed together as a unit. A portion of the stomach, as well as the gallbladder and a portion of the bile duct, may be removed as well.

Typically, the Whipple procedure is performed most commonly to treat pancreatic cancer, but also cancer of the duodenum and pancreatic ducts, and occasionally, chronic pancreatitis. Also known by its technical name, pancreaticoduodenectomy, the Whipple procedure received its more familiar name after its founder, Dr. Allen Whipple, who was Chairman of the Department of Surgery at NewYork-Presbyterian/Columbia for twenty-five years.

The robotic Whipple procedure is significant for a few of its advantages, notably that it improves cosmetic outcomes and reduces post-operative pain when compared to the traditional approach. Another potential advantage, currently under evaluation, includes shortening patients’ recovery time before starting chemotherapy. “If we can enhance patients’ recovery, they can begin their post-operative chemotherapy sooner,” explains Dr. Chabot. Currently, it’s common for patients to wait eight to ten weeks after surgery before starting chemotherapy. “We would much prefer if we started at five to six weeks,” says Dr. Chabot.

The Pancreas Center prepared for the procedure with a lot of work and effort, to ensure the right team was in place with a strong background in both robotics and the Whipple procedure itself. “Dr. Woo is one of the world’s leading experts in upper abdominal robotic surgery, having performed over two hundred robotic operations for gastric cancer. I have extensive experience in pancreatic surgery, especially with the Whipple procedure,” explained Dr. Chabot. Dr. Woo and Dr. Chabot also recruited a dedicated operating room staff with expertise in robotic surgery, spanning numerous departments. “Together, we performed a multitude of simpler pancreatic operations until we developed a sufficient comfort level to complete this more complex surgery.”

At the Pancreas Center, the first robotic Whipple procedure was a big step forward but there’s still work to be done according to Dr. Chabot, “We’re not going to start doing every Whipple procedure robotically. I believe in three to four years, however, we might be doing half of our Whipple procedures robotically.” Dr. Chabot concluded, “We must always assess the patients’ needs and perform the treatment best for the patient.”

For more information about The Pancreas Center, please visit our website at pancreasmd.org or call our new patient coordinator at 212-305-9467.

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Recent Questions About the Usefulness of Mammography

March 7, 2014

TweetMany patients have inquired about a recent study in the British Medical Journal by Canadian researchers who found that mammography did not reduce death rates from breast cancer and may even have harmed some women by leading to unnecessary surgery, radiation, and chemotherapy. A vast majority of physicians, researchers, and breast radiologists have criticized the […]

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Redefining Gastric Cancer Treatment: An Interdisciplinary Approach

February 25, 2014

TweetThis Blog Talk Radio program has already occurred. Please view the on-demand copy at the bottom of this post. Gastric cancer is a curable disease with effective treatment options.  When discovered in its early stages, gastric cancer can be eliminated with complete resection of the tumor alone.  The treatment of advanced gastric cancer requires a […]

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How Is Gastric Cancer Diagnosed?

February 25, 2014

TweetGastric cancer is hard to detect in early stages because symptoms are uncommon and nonspecific.  When symptoms do occur, they can easily be mistaken for more common ailments such as a stomach virus. Gastric cancer symptoms may include a loss of appetite, indigestion, nausea, stomach discomfort, heartburn, black stool, vomiting, unintentional weight loss, feeling full […]

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Advancement in Gastric Cancer Treatment: Robotic Surgery

February 25, 2014

TweetSpecially trained surgeons in gastric cancer operations and robotic surgery can offer select patients a minimally invasive approach to gastric cancer surgery.  The traditional open operations for gastric cancer are performed through large abdominal incisions; however, for the past thirty years, experts in Korea and Japan and more recently in the U.S. and Europe have […]

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Study Finds Exercise Improves Joint Pain in Women Taking Aromatase Inhibitors for Breast Cancer

February 19, 2014

TweetOne of the main reasons that women have low quality of life while taking hormonal therapy is their side effects, says Dawn Hershman, MD, MS, Associate Professor of Medicine and Epidemiology and leader of the breast cancer program at the Herbert Irving Comprehensive Cancer Center. While taking aromatase inhibitors (such as exemestane), the most common […]

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Innovations in Breast Cancer: Intraoperative Radiation Therapy Update

February 14, 2014

TweetPrevious posts have informed our readers about an innovative breast cancer therapy, intraoperative radiation therapy (IORT), which became available at the Breast Center during the summer of 2013.  New York-Presbyterian/Columbia University Medical Center is one of the first institutions in the New York metropolitan area to offer IORT, which entails a single dose of radiation […]

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Gastric Cancer Registry

February 13, 2014

TweetGastric cancer is the second leading cancer killer in the world. It is estimated that over 10,000 will die from gastric cancer this year in the United States. One of the reasons for its poor mortality rate is its late diagnosis. Unfortunately, in the United States, more than 60% of gastric cancer cancers are diagnosed […]

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“Call Dr. Chabot and don’t stop living”

February 5, 2014

TweetJan Hilgeman’s story I wasn’t angry, and I never asked “why” I was the one with this diagnosis; it is a question without an answer. Getting the best treatment available while living my life as normally as possible was my job; it never occurred to me that there was any other way. If cancer was […]

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